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- Document 0670
- DOCN M94A0670
- TI Length of phases of HIV disease defined by CD4 lymphocyte count.
- DT 9412
- AU Carlin JB; Clinical Epidemiology & Biostatistics Unit, Royal Children's;
- Hospital, Melbourne.
- SO Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:47 (abstract no. SE3).
- Unique Identifier : AIDSLINE ASHM5/94348985
- AB OBJECTIVES: To review and synthesize available knowledge on the usual
- lengths of time spent by persons with HIV in each of the clinically
- defined phases: (1) CD4 count > 500 (x 10(6)/l), (2) CD4 count 200-500,
- (3) CD4 count < 200 but no AIDS-defining illness, (4) AIDS. METHODS:
- Extensive literature review performed of all papers reporting relevant
- data or statistical modelling. Estimates of phase length were derived
- from published models both mathematically and using computer
- simulations. RESULTS: Few researchers have studied the natural history
- of HIV disease in a way that allows estimates of the length of phases
- defined by CD4-count, because of the difficulty of performing necessary
- cohort studies and the natural variability of lymphocyte counts. From
- three independent studies, estimates ranging between: (1) 4.1 to 8.2
- years, (2) 3.9 to 5.2 years and (3) 1.6 to 2.6 years were derived for
- the mean duration of the first three phases. Variances are large,
- especially for the first phase. CONCLUSIONS: The summary values obtained
- in this analysis are useful for economic analysis and health services
- planning and may have some limited value for clinical prognosis.
- DE Acquired Immunodeficiency Syndrome/CLASSIFICATION/DIAGNOSIS/
- *IMMUNOLOGY Cohort Studies Computer Simulation Human HIV
- Infections/CLASSIFICATION/DIAGNOSIS/*IMMUNOLOGY *Leukocyte Count
- Models, Statistical T4 Lymphocytes/*IMMUNOLOGY MEETING ABSTRACT
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
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-